David harrich biography

Brief Bio. University of California Los Angeles.
David HARRICH | Cited by 5159 | of QIMR Berghofer Medical Research Institute, Brisbane (QIMR) | Read 115 publications | Contact David HARRICH.
Presenter: Dr Tushar Kumeria from University of New South Wales and David Harrich from QIMR Berghofer Medical Research Institute.

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Abstract

SUMMARY

The prokaryotic translation elongation factors were identified as essential cofactors for RNA-dependent RNA polymerase activity of the bacteriophage Qβ more than 40 years ago. A growing body of evidence now shows that eukaryotic translation elongation factors (eEFs), predominantly eEF1A, acting in partially characterized complexes sometimes involving additional eEFs, facilitate virus replication. The functions of eEF1A as a protein chaperone and an RNA- and actin-binding protein enable its “moonlighting” roles as a virus replication cofactor. A diverse group of viruses, from human immunodeficiency type 1 and West Nile virus to tomato bushy stunt virus, have adapted to use eEFs as cofactors for viral transcription, translation, assembly, and pathogenesis. Here we review the mechanisms used by viral pathogens to usurp these abundant cellular proteins for their replication.

INTRODUCTION

Human eukaryotic translation elongation factor 1A (eEF1A) is a protein subunit of the eukaryotic translation elongation 1 complex (eEF1), which in metazoans is composed of eEF1A,

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Research Seminars

2025 Seminars

Speaker

Prof Julia Frunzke, Forschungszentrum Jülich,Heinrich-Heine-Universität Düsseldorf; https://www.fz-juelich.de/profile/frunzke_j

Title:
Phage-host Interactions: Warfare, Alliances, and Application

Venue & Time
New Lecture Room, Thursday 20^th February 2025

Speaker

Dr James Connolly, MRC Career Development Fellow and Principal Research Associate at Newcastle University’s Bioscience Institute

Title:
Regulatory flexibility as a driver of niche-specific Escherichia coli pathogenesis

Venue & Time
New Lecture Room, Thursday 13^th February 2025

Bio: The overarching goal of our research is to uncover the mechanisms underlying how pathogenic Escherichia coli are capable of infecting different sites of the human body - such as the gut, urinary tract and bloodstream. Pathogenic strains of E. coli employ numerous virulence and fitness enhancing factors to achieve this. These factors are often encoded on horizontally acquired genomic islands and must be precisely regulated in response to

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Editorial Board

Editors-in-Chief

Johnson Mak, PhD, Institute for Glycomics, Griffith University, Australia
Professor Mak is a native of Hong Kong who undertook his undergraduate and post-graduate training at McGill University in Montreal, Canada. During his PhD Johnson worked with Professor Lawrence Kleiman at the McGill AIDS Centre studying packaging of primer tRNA into HIV. He subsequently moved to Melbourne, Australia to continue work on HIV assembly at the Burnet Institute under the guidance of Professor Suzanne Crowe. He is currently a Professor at the Institute for Glycomics, Griffith University, Gold Coast. He has a broad research portfolio in HIV having studied primer tRNAs in retroviruses, genomic RNA packaging and dimerization, cholesterol and lipids in HIV, viral-host interactions, imaging of HIV and analysis of recombination and mutation in HIV using next generation sequencing. His team pioneered the production of full-length recombinant HIV Gag for biochemical and biophysical analyses of HIV assembly. Recently Johnson and his team have described a pre-entry prim